The periaqueductal grey in chronic low back pain: dysregulated metabolites and function | medRxiv
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Frontiers | Brainstem Pain-Modulation Circuitry and Its Plasticity in Neuropathic Pain: Insights From Human Brain Imaging Investigations
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In this week's #PAIN Featured Image, Sirucek et al. present clinical evidence for altered amygdala-medial prefrontal cortex (mPFC)-periaqueductal gray (PAG) connectivity patterns in chronic pain and potential consequences for PAG-driven descending pain
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Frontiers | The Contribution of the Descending Pain Modulatory Pathway in Opioid Tolerance
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What is the role of the periaqueductal gray in pain modulation?
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Nociception Pathways: | ditki medical and biological sciences
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Pain Transmission Pathway – Opioid Peptides
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Just published in JOSPT 🔥 Pain Science in Practice: How Does Descending Modulation of Pain Work? 👉 To understand the neuroscience of pain relief, one must know about the descending pain modulatory
Figure 3 from Basic anatomy and physiology of pain pathways. | Semantic Scholar
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Neuroanatomy, Periaqueductal Gray | Treatment \u0026 Management | Point of Care
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Descending pain modulation
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Descending Control Mechanisms and Chronic Pain
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Frontiers | Monoamines as Drug Targets in Chronic Pain: Focusing on Neuropathic Pain
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EdTech Books
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Periaqueductal Gray Sheds Light on Dark Areas of Psychopathology: Trends in Neurosciences
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Periaqueductal gray | Neurology
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Pain and Nociception – Foundations of Neuroscience
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Cell type-specific dissection of sensory pathways involved in descending modulation: Trends in Neurosciences
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The 'in's and out's' of descending pain modulation from the rostral ventromedial medulla: Trends in Neurosciences
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The role of pain modulation pathway and related brain reg...
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A pontine center in descending pain control: Neuron
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The Therapeutic Potential of Dual NMR (NOP/MOP) Agonism in Pain Management | Pain and Therapy
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9.2 Somatosensation in the Central Nervous System - Introduction to Behavioral Neuroscience | OpenStax
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The Cerebral Signature for Pain Perception and Its Modulation: Neuron
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Divergent modulation of pain and anxiety by GABAergic neurons in the ventrolateral periaqueductal gray and dorsal raphe | Neuropsychopharmacology
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Pain – Foundations of Neuroscience
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Modulating neuroplasticity for chronic pain relief: noninvasive neuromodulation as a promising approach | Experimental \u0026 Molecular Medicine
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Pain: Types and Pathways | Concise Medical Knowledge
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Periaqueductal gray - Wikipedia
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Pain Perception and Modulation: Fundamental Neurobiology and Recent Advances - Strien - 2025 - European Journal of Neuroscience - Wiley Online Library
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Whole‐brain monosynaptic inputs to lateral periaqueductal gray glutamatergic neurons in mice - Ma - 2023 - CNS Neuroscience \u0026 Therapeutics - Wiley Online Library
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Pain-Modulation - Physiopedia
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A systematic review on descending serotonergic projections and modulation of spinal nociception in chronic neuropathic pain and after spinal cord stimulation - Lonne Heijmans, Martijn R Mons, Elbert A Joosten, 2021
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Brainstem Pain-Control Circuitry Connectivity in Chronic Neuropathic Pain | Journal of Neuroscience
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Chronic Pain and Its Treatment (Chapter 9) - Stahl's Essential Psychopharmacology
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Anatomo-physiological basis and applied techniques of electrical neuromodulation in chronic pain | Journal of Anesthesia, Analgesia and Critical Care
The plasticity of descending controls in pain: translational probing - Bannister - 2017 - The Journal of Physiology - Wiley Online Library
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An introduction to pain pathways and mechanisms | British Journal of Hospital Medicine
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Frontiers | Neuroanatomy of spinal nociception and pain in dogs and cats: a practical review for the veterinary clinician
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Glial Modulation of Pain: A Step Beyond | Journal of Neuroscience
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The Interplay between Chronic Pain, Opioids, and the Immune System - Valentina Malafoglia, Sara Ilari, Laura Vitiello, Michael Tenti, Eleonora Balzani, Carolina Muscoli, William Raffaeli, Antonello Bonci, 2022
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The association between pain‐induced autonomic reactivity and descending pain control is mediated by the periaqueductal grey - Makovac - 2021 - The Journal of Physiology - Wiley Online Library
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Descending pain modulation
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An analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray in rats | Nature Communications
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Descending pain modulation
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Cell type-specific dissection of sensory pathways involved in descending modulation: Trends in Neurosciences
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T-type channels control the opioidergic descending analgesia at the low threshold-spiking GABAergic neurons in the periaqueductal gray | PNAS
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This week's #PAIN Featured Figure depicts the hypothesis of multiple factors influencing the top-down pain modulation in fibromyalgia. Gerra et al.'s study suggests a link between dopaminergic dysfunction and vulnerability to chronic
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The 'in's and out's' of descending pain modulation from the rostral ventromedial medulla: Trends in Neurosciences
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Imaging Attentional Modulation of Pain in the Periaqueductal Gray in Humans | Journal of Neuroscience
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Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation | bioRxiv
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Brainstem modulation of nociception by periaqueductal gray neurons expressing the mu-opioid receptor | bioRxiv
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Somatostatin Neurons from Periaqueductal Gray to Medulla Facilitate Neuropathic Pain in Male Mice - The Journal of Pain
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The Contribution of the Descending Pain Modulatory Pathway in Opioid Tolerance
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The periaqueductal grey in chronic low back pain: dysregulated metabolites and function | medRxiv
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The Periaqueductal Grey
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Yin-and-yang bifurcation of opioidergic circuits for descending analgesia at the midbrain of the mouse | PNAS
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Descending pain modulation
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Pain Modulation Pathway Mechanisms in El Paso, TX
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The periaqueductal grey in chronic low back pain: dysregulated metabolites and function | medRxiv
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Noradrenergic Locus Coeruleus pathways in pain modulation - Neuroscience
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Pain and Placebo Physiology | PM\u0026R KnowledgeNow
Pain: Types and Pathways | Concise Medical Knowledge
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Case Report: Multidimensional Analgesia via Asymmetric Dual-Target Deep Brain Stimulation of the Periaqueductal Gray and Ventral Posterior Thalamus in Central Post-stroke Pain | Neurology and Therapy
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Functional representation of trigeminal nociceptive input in the human periaqueductal gray | Science Advances
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Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation | Science Advances
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Physiology of pain (Chapter 19) - Fundamentals of Anaesthesia
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Pain part 1: introduction to pain | Dental Update
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Hypofunction of Glutamatergic Neurotransmission in the Periaqueductal Gray Contributes to Nerve-Injury-Induced Neuropathic Pain | Journal of Neuroscience
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PPT - Dr Abdulrahman Alhowikan Collage of medicine Physiology Dep. PowerPoint Presentation - ID:1892406
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Somatostatin Neurons from Periaqueductal Gray to Medulla Facilitate Neuropathic Pain in Male Mice - The Journal of Pain
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Effects of Injury on Modulation of Nociception 📘 Great illustration by Martyn et al. (2019, NEJM) 👉 Tissue injury cause local and often systemic inflammatory responses. These responses launch a cascade of
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Descending pain modulation
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Spinal cord stimulation in chronic pain: evidence and theory for mechanisms of action | Bioelectronic Medicine
The cellular mechanism by which the rostral ventromedial ...
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Pathology of pain and its implications for therapeutic interventions | Signal Transduction and Targeted Therapy
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Figure 7 from Neuroimaging of the periaqueductal gray: State of the field | Semantic Scholar
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Brainstem Pain-Control Circuitry Connectivity in Chronic Neuropathic Pain | Journal of Neuroscience
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Figure 1 from Factors Affecting Pain Intensity and Postoperative Oxycodone Requirement : Clinical and Genetic Perspectives | Semantic Scholar
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Overview of Pain Physiology - Nursing Clinics
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Dena Kofahi Lana Mango Hadeel Alkayed Faisal Mohammad
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Understanding Pain
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Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation | Science Advances
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Whole‐brain monosynaptic inputs to lateral periaqueductal gray glutamatergic neurons in mice - Ma - 2023 - CNS Neuroscience \u0026 Therapeutics - Wiley Online Library
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Top-down control of the descending pain modulatory system drives placebo analgesia | bioRxiv
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The Physiology of Pain Mechanisms: From the Periphery to the Brain - Rheumatic Disease Clinics
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Sleep \u0026 Headache
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Descending pain modulation
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Yin-and-yang bifurcation of opioidergic circuits for descending analgesia at the midbrain of the mouse | PNAS
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Re-examining the Mysterious Role of the Cerebellum in Pain | Journal of Neuroscience
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Pain Perception and Modulation: Fundamental Neurobiology and Recent Advances - Strien - 2025 - European Journal of Neuroscience - Wiley Online Library